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One type of exercise may alleviate or even delay the symptoms of Alzheimer's disease

One type of exercise may alleviate or even delay the symptoms of Alzheimer's disease
Source: sciencealert.com

Researchers have discovered that strengthening your muscles can help delay the onset of Alzheimer's symptoms.


Strong evidence has been found by Brazilian researchers from the Federal University of So Paulo and the University of So Paulo that resistance training, in which muscles are worked against a weight or force, may have significant effects on the brains of dementia patients.


Before you swiftly recharge your rec center participation or break out the home gym equipment, it merits remembering that this was a mouse model review. Nevertheless, humans are likely to follow the same rules.


According to neuroscientist Henrique Correia Campos of the Federal University of So Paulo (UNIFESP), "This confirms that physical activity can reverse neuropathological alterations that cause clinical symptoms of the disease."


Before being compared to mice without the mutation, mice with a genetic mutation that causes beta-amyloid plaques to build up in the brain, as seen in people with Alzheimer's disease, were put through a four-week resistance exercise training program with ladders and weights.


The weight-training mice's plasma levels of the hormone corticosterone were comparable to those of the control group's mice. This was in addition to the fact that exercise reduced plaque buildup. In humans, corticosterone is equivalent to cortisol, which is produced when the body is under stress and has been linked to Alzheimer's disease in the past.


The beta-amyloid plaque mice were also tested for anxiety because Alzheimer's disease and other forms of dementia can cause wandering and restlessness in mice. Here again, the obstruction preparation appeared to help.


Neuroscientist Deidiane Elisa Ribeiro from the University of So Paulo in Brazil reports, "We also observed the animals' behavior to assess their anxiety in the open field test and found that resistance exercise reduced hyperlocomotion to similar levels to the controls among mice with the phenotype associated with Alzheimer's."


In addition to considering potential differences in human and mouse physiology, the precise role that protein plaques play in Alzheimer's disease is still up for debate, which raises questions regarding the extent to which dementia patients might benefit from resistance training.


However, resistance training has a few drawbacks, particularly as we get older. It helps with balance, makes everyday tasks easier to do, and boosts muscle mass and strength as well as bone density. It's also one of those exercises that gets easier to keep up as you get older, so there aren't many reasons not to do it every day. The earlier, the better!


It appears that this kind of exercise can both prevent and treat dementia, assuming the same results are found in humans. Previous research has shown that this particular type of exercise can strengthen connections in the brain that are likely to break as dementia progresses.


Although resistance training may be able to aid in all three areas, researchers are still trying to decipher the connection between Alzheimer's disease, its underlying causes, and the general effects of aging.


"The super conceivable justification behind this adequacy is the calming activity of obstruction work out," says UNIFESP neurophysiologist Beatriz Monteiro Longo.


Frontiers in Neuroscience has published the research.

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